MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.

ABSTRACT:

Background

MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma.

Design and methods

MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human microRNAs. Tandem gene expression profiles were obtained for predicting microRNA targets.

Results

The expression of 133 microRNAs was significantly different (> 2-fold; P<0.05) between follicular lymphoma and follicular hyperplasia. Forty-four microRNAs in three groups generated a unique follicular lymphoma signature. Of these, ten microRNAs were increased (miR-193a-5p, -193b*, -345, -513b, -574-3p, -584, -663, -1287, -1295, and -1471), 11 microRNAs were decr

SUBMITTER: Wang W 

PROVIDER: S-EPMC3347661 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature