Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma.

ABSTRACT:

Background

Genetic abnormalities are common in patients with multiple myeloma, and may deregulate gene products involved in tumor survival, proliferation, metabolism and drug resistance. In particular, translocations may result in a high expression of targeted genes (termed spike expression) in tumor cells. We identified spike genes in multiple myeloma cells of patients with newly-diagnosed myeloma and investigated their prognostic value.

Design and methods

Genes with a spike expression in multiple myeloma cells were picked up using box plot probe set signal distribution and two selection filters.

Results

In a cohort of 206 newly diagnosed patients with multiple myeloma, 2587 genes/expressed sequence tags with a spike expression were identified. Some spike genes were

SUBMITTER: Kassambara A 

PROVIDER: S-EPMC3347668 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature