Epithelial cell organization suppresses Myc function by attenuating Myc expression.

ABSTRACT: c-Myc is an oncogene transcription factor that causes cancer in many settings, including solid tumors that arise in the context of organized tissue structures. Given that disruption of tissue architecture frequently occurs in cancer, there is considerable interest in how cell organization impacts oncogene function. A previous report found that organization of mammary epithelial cells into defined 3-dimensional structures renders them insensitive to the effects of retrovirus-mediated overexpression of Myc, leading to the notion that organization tempers the sensitivity of individual cells to Myc activity. In this article, we report that epithelial cell organization does not profoundly alter Myc activity but, instead, suppresses Myc by modulating its expression. We show that the morphogenesi

SUBMITTER: Simpson DR 

PROVIDER: S-EPMC3347713 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature