Evolutionary dynamics of human autoimmune disease genes and malfunctioned immunological genes.

ABSTRACT:

Background

One of the main issues of molecular evolution is to divulge the principles in dictating the evolutionary rate differences among various gene classes. Immunological genes have received considerable attention in evolutionary biology as candidates for local adaptation and for studying functionally important polymorphisms. The normal structure and function of immunological genes will be distorted when they experience mutations leading to immunological dysfunctions.

Results

Here, we examined the fundamental differences between the genes which on mutation give rise to autoimmune or other immune system related diseases and the immunological genes that do not cause any disease phenotypes. Although the disease genes examined are analogous to non-disease genes in product, e

SUBMITTER: Podder S 

PROVIDER: S-EPMC3347981 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature