Prevalence of genetic variants associated with inflammatory bowel disease in a healthy First Nations cohort.

ABSTRACT:

Background

Inflammatory bowel disease is the result of both genes and environment. Canadian First Nations people, despite living in a region with a high prevalence of inflammatory bowel disease, are relatively protected from this disease. We aimed to compare the carriage of genetic variants associated with inflammatory bowel disease in healthy First Nations and white people.

Methods

DNA was extracted from the venous blood of healthy First Nations (n = 340) and white (n = 285) participants from Manitoba. Genotyping was performed for 69 single nucleotide polymorphisms (SNPs) with known or suspected associations with inflammatory bowel disease. We compared the genotypes between groups by logistic regression, adjusting for multiple testing. We calculated a risk score for the NOD

SUBMITTER: Murdoch TB 

PROVIDER: S-EPMC3348221 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature