Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes.

ABSTRACT:

Purpose

Renal cell carcinoma is the eighth most common cancer in the United States and clear cell renal carcinoma is the most common type. Many signaling pathways are implicated in clear cell renal carcinoma development, including the inflammation pathway. However, less is known about how gene expression variation in this pathway influences clear cell renal carcinoma development and clinical outcomes.

Materials and methods

Gene expression in tumor and adjacent normal tissues from 93 patients was detected using a genome-wide expression array. A panel of 661 inflammation related genes was then analyzed. Differential expression patterns between tumor and normal tissues were identified. Association with recurrence or survival was evaluated with genes showing significant associat

SUBMITTER: Tan W 

PROVIDER: S-EPMC3348612 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature