Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

Traditional genome-wide association studies (GWASs) of large cohorts of subjects with chronic obstructive pulmonary disease (COPD) have successfully identified novel candidate genes, but several other plausible loci do not meet strict criteria for genome-wide significance after correction for multiple testing.

Objectives

The authors hypothesise that by applying unbiased weights derived from unique populations we can identify additional COPD susceptibility loci. Methods The authors performed a homozygosity haplotype analysis on a group of subjects with and without COPD to identify regions of conserved homozygosity haplotype (RCHHs). Weights were constructed based on the frequency of these RCHHs in case versus controls, and used to adjust the p values from a large co

SUBMITTER: Brehm JM 

PROVIDER: S-EPMC3348619 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature