Altered microstructural connectivity in juvenile myoclonic epilepsy: the missing link.

ABSTRACT:

Objectives

Juvenile myoclonic epilepsy (JME) is characterized by myoclonic jerks of the upper limbs, often triggered by cognitive stressors. Here we aim to reconcile this particular seizure phenotype with the known frontal lobe type neuropsychological profile, photosensitivity, hyperexcitable motor cortex, and recent advanced imaging studies that identified abnormal functional connectivity of the motor cortex and supplementary motor area (SMA).

Methods

We acquired fMRI and diffusion tensor imaging (DTI) in a cohort of 29 patients with JME and 28 healthy control subjects. We used fMRI to determine functional connectivity and DTI-based region parcellation and voxel-wise comparison of probabilistic tractography data to assess the structural connectivity profiles of the mesial f

SUBMITTER: Vollmar C 

PROVIDER: S-EPMC3348847 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature