Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).

ABSTRACT:

Background

Congenital toxoplasmosis is a severe, life-altering disease in the United States. A recently developed enzyme-linked immunosorbent assay (ELISA) distinguishes Toxoplasma gondii parasite types (II and not exclusively II [NE-II]) by detecting antibodies in human sera that recognize allelic peptide motifs of distinct parasite types.

Methods

ELISA determined parasite serotype for 193 congenitally infected infants and their mothers in the National Collaborative Chicago-based Congenital Toxoplasmosis Study (NCCCTS), 1981-2009. Associations of parasite serotype with demographics, manifestations at birth, and effects of treatment were determined.

Results

Serotypes II and NE-II occurred in the United States with similar proportions during 3 decades. For persons diag

SUBMITTER: McLeod R 

PROVIDER: S-EPMC3348955 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature