Family-based association study of early growth response gene 3 with child bipolar I disorder.

ABSTRACT:

Background

The risk for relapse of child bipolar I disorder (BP-I) is highly correlated with environmental factors. Immediate early genes of the early growth response (EGR) gene family are activated at high levels in the brain in response to environmental events, including stress, and mediate numerous neurobiological processes that have been associated with mental illness risk. The objective of this study is to evaluate whether single nucleotide polymorphisms (SNPs) in EGR genes are associated with the risk to develop child bipolar I disorder.

Methods

To investigate whether EGR genes may influence susceptibility to child bipolar I disorder (BP-I), we used Family Based Association Tests to examine whether SNPs in each of the EGR genes were associated with illness in 49 famili

SUBMITTER: Gallitano AL 

PROVIDER: S-EPMC3349283 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature