Dataset Information

Obesity susceptibility loci and dietary intake in the Look AHEAD Trial.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear.

Objective

The objective was to determine the association between obesity susceptibility loci and dietary intake.

Design

The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site.