Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies.

ABSTRACT:

Background

[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) is a valuable tool for monitoring response to therapy in oncology. In longitudinal studies, however, patients are not scanned in exactly the same position. Rigid and non-rigid image registration can be applied in order to reuse baseline volumes of interest (VOI) on consecutive studies of the same patient. The purpose of this study was to investigate the impact of various image registration strategies on standardized uptake value (SUV) and metabolic volume test-retest variability (TRT).

Methods

Test-retest whole-body [18F]FDG PET/CT scans were collected retrospectively for 11 subjects with advanced gastrointestinal malignancies (colorectal carcinoma). Rigid and non-rigid image registration

SUBMITTER: van Velden FH 

PROVIDER: S-EPMC3349514 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature