Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events.

ABSTRACT:

Background

Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting the urgent need for more informative biomarkers. Androgen receptor (AR) has been implicated in breast carcinogenesis however its potential to be an informative biomarker has yet to be fully explored. In this study, AR protein levels were determined in a cohort of 73 Grade III invasive breast ductal adenocarcinomas.

Methods

The levels of Androgen receptor protein in a cohort of breast tumour samples was determined by immunohistochemistry and the results were compared with clinical characteristics, including survival. The role of defects in the regulation of Androgen receptor gene expression were examined by m

SUBMITTER: Peters KM 

PROVIDER: S-EPMC3349557 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature