Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs.

ABSTRACT: Pseudomonas aeruginosa is a highly adaptable bacterium that thrives in a broad range of ecological niches and can infect multiple hosts as diverse as plants, nematodes and mammals. In humans, it is an important opportunistic pathogen. This wide adaptability correlates with its broad genetic diversity. In this study, we used a deep-sequencing approach to explore the complement of small RNAs (sRNAs) in P. aeruginosa as the number of such regulatory molecules previously identified in this organism is relatively low, considering its genome size, phenotypic diversity and adaptability. We have performed a comparative analysis of PAO1 and PA14 strains which share the same host range but differ in virulence, PA14 being considerably more virulent in several model organisms. Altogether, we have iden

SUBMITTER: Ferrara S 

PROVIDER: S-EPMC3349714 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature