NIBBS-search for fast and accurate prediction of phenotype-biased metabolic systems.

ABSTRACT: Understanding of genotype-phenotype associations is important not only for furthering our knowledge on internal cellular processes, but also essential for providing the foundation necessary for genetic engineering of microorganisms for industrial use (e.g., production of bioenergy or biofuels). However, genotype-phenotype associations alone do not provide enough information to alter an organism's genome to either suppress or exhibit a phenotype. It is important to look at the phenotype-related genes in the context of the genome-scale network to understand how the genes interact with other genes in the organism. Identification of metabolic subsystems involved in the expression of the phenotype is one way of placing the phenotype-related genes in the context of the entire network. A metaboli

SUBMITTER: Schmidt MC 

PROVIDER: S-EPMC3349732 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature