ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes.

ABSTRACT: Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are required to generate specific functional outcomes that enable distinct gene expression programmes to be controlled by a particular transcription factor. Here we used ChIP-seq to uncover two distinct binding modes for the ETS transcription factor ELK1. In one mode, other ETS transcription factors can bind regulatory regions in a redundant fashion; in the second, ELK1 binds in a unique fashion to another set of genomic targets. Each binding mode is associated with different binding site features and also distinct regulatory outcomes. Furthermore, the t

SUBMITTER: Odrowaz Z 

PROVIDER: S-EPMC3349735 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature