Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients.

ABSTRACT:

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Liver failure resulting from chronic hepatitis C virus (HCV) infection is a major cause for liver transplantation worldwide. Recurrent infection of the graft is universal in HCV patients after transplant and results in a rapid progression to severe fibrosis and end-stage liver disease in one third of all patients. No single clinical variable, or combination thereof, has, so far, proven accurate in identifying patients at risk of hepatic decompensation in the transplant setting. A combination of longitudinal, dimensionality reduction and categorical analysis of the transcriptome from 111 liver biopsy specimens taken from 57 HCV-infected patients over time identified a molecular signature of gene expression of patients at risk of developing severe fibrosis. Significantly,

SUBMITTER: Rasmussen AL 

PROVIDER: S-EPMC3349763 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature