Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.

ABSTRACT: An immature intestinal epithelial barrier may predispose infants and children to many intestinal inflammatory diseases, such as infectious enteritis, inflammatory bowel disease, and necrotizing enterocolitis. Understanding the factors that regulate gut barrier maturation may yield insight into strategies to prevent these intestinal diseases. The claudin family of tight junction proteins plays an important role in regulating epithelial paracellular permeability. Previous reports demonstrate that rodent intestinal barrier function matures during the first 3 weeks of life. We show that murine paracellular permeability markedly decreases during postnatal maturation, with the most significant change occurring between 2 and 3 weeks. Here we report for the first time that commensal bacterial colo

SUBMITTER: Patel RM 

PROVIDER: S-EPMC3349863 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature