Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.

ABSTRACT: A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.

SUBMITTER: Wyche TP 

PROVIDER: S-EPMC3349995 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature