Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study.

ABSTRACT:

Background

The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy.

Methods/design

A total of 240 patients will be recruited, evenly sampled among different analysis groups including tumors of the brain, skull base, head and neck region, upper gastrointestinal tract including the liver, lower gastrointestinal tract, prostate and pelvic region. From the comparison of the measured activity with the planned dose and its corresponding simulated activity distribution, conclusions on the delivered treatment will be inferred and, in case of significant deviations, correction strategies will be elaborated.

Discuss

SUBMITTER: Combs SE 

PROVIDER: S-EPMC3350391 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature