The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes.

ABSTRACT:

Background

Hypercortisolemia has been suggested as a primary hormonal mediator of whole-body catabolism following severe burn injury. Ketoconazole, an anti-fungal agent, inhibits cortisol synthesis. We, therefore, studied the effect of ketoconazole on post-burn cortisol levels and the hyper-catabolic response in a prospective randomized trial (block randomization 2:1).

Methodology/principal findings

Fifty-five severely burned pediatric patients with >30% total body surface area (TBSA) burns were enrolled in this trial. Patients were randomized to receive standard care plus either placebo (controls, n = 38) or ketoconazole (n = 23). Demographics, clinical data, serum hormone levels, serum cytokine expression profiles, organ function, hypermetabolism measures, muscle protein s

SUBMITTER: Jeschke MG 

PROVIDER: S-EPMC3350497 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature