Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage.

ABSTRACT:

Context and objective

The etiology of miscarriage is often multifactorial. One major cause, immunological rejection of the fetus, has not been clearly elucidated. Our aim was to establish whether the semaphorin CD100, its natural receptor CD72, and the glycoprotein CD45, implicated in immune mechanisms, are involved in pregnancy loss by examining their placental expression with real-time PCR, immunohistochemistry and western blotting techniques.

Patients

Placenta tissue from 72 Caucasian women undergoing surgical uterine evacuation due to early spontaneous pregnancy loss between the 8(th) and 12(th) week of gestation was divided into four groups based on miscarriage number. Gestational age-matched placentas from 18 healthy women without a history of miscarriage undergoing vo

SUBMITTER: Lorenzi T 

PROVIDER: S-EPMC3350501 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature