Exploring protein dynamics space: the dynasome as the missing link between protein structure and function.

ABSTRACT: Proteins are usually described and classified according to amino acid sequence, structure or function. Here, we develop a minimally biased scheme to compare and classify proteins according to their internal mobility patterns. This approach is based on the notion that proteins not only fold into recurring structural motifs but might also be carrying out only a limited set of recurring mobility motifs. The complete set of these patterns, which we tentatively call the dynasome, spans a multi-dimensional space with axes, the dynasome descriptors, characterizing different aspects of protein dynamics. The unique dynamic fingerprint of each protein is represented as a vector in the dynasome space. The difference between any two vectors, consequently, gives a reliable measure of the difference bet

SUBMITTER: Hensen U 

PROVIDER: S-EPMC3350514 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature