Rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is the third most incident cancer and cause of cancer-related death in the United States. MicroRNAs, a class of small non-coding RNAs, have been implicated in the pathogenesis and prognosis of colorectal cancer, although few studies have examined the relationship between germline mutation in the microRNAs with risk and prognosis. We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer.

Methods and results

A cohort consisting of 245 cases and 446 controls was genotyped for rs4919510. The frequency of the GG genotype was significantly higher in African Americans (15%) compared to Caucasians (3%) controls. There was no significant association between rs4919510 and colorectal ca

SUBMITTER: Ryan BM 

PROVIDER: S-EPMC3350523 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature