Prolactin receptor in primary hyperparathyroidism--expression, functionality and clinical correlations.

ABSTRACT:

Background

Primary hyperparathyroidism (PHPT) is an endocrine disorder most commonly affecting women, suggesting a role for female hormones and/or their receptors in parathyroid adenomas. We here investigated the prolactin receptor (PRLr) which is associated with tumours of the breast and other organs.

Methodology/principal findings

PRLr expression was investigated in a panel of 37 patients with sporadic parathyroid tumours and its functionality in cultured parathyroid tumour cells. In comparison with other tissues and breast cancer cells, high levels of prolactin receptor gene (PRLR) transcripts were demonstrated in parathyroid tissues. PRLr products of 60/70 kDa were highly expressed in all parathyroid tumours. In addition varying levels of the 80 kDa PRLr isoform, with kn

SUBMITTER: Haglund F 

PROVIDER: S-EPMC3350524 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature