Systematic discovery of structural elements governing stability of mammalian messenger RNAs.

ABSTRACT: Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour. Despite recent efforts, the vast landscape of RNA regulatory elements remains largely uncharacterized. A long-standing obstacle is the contribution of local RNA secondary structure to the definition of interaction partners in a variety of regulatory contexts, including--but not limited to--transcript stability, alternative splicing and localization. There are many documented instances where the presence of a structural regulatory element dictates alternative splicing patterns (for example, human cardiac troponin T) or affects other aspects of RNA biology. Thus, a full characterization of post-transcriptional regulatory programs

SUBMITTER: Goodarzi H 

PROVIDER: S-EPMC3350620 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature