Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy.

ABSTRACT:

Background

Several arrhythmogenic mechanisms have been inferred from animal heart failure models. However, the translation of these hypotheses is difficult because of the lack of functional human data. We aimed to investigate the electrophysiological substrate for arrhythmia in human end-stage nonischemic cardiomyopathy.

Methods and results

We optically mapped the coronary-perfused left ventricular wedge preparations from human hearts with end-stage nonischemic cardiomyopathy (heart failure, n=10) and nonfailing hearts (NF, n=10). Molecular remodeling was studied with immunostaining, Western blotting, and histological analyses. Heart failure produced heterogeneous prolongation of action potential duration resulting in the decrease of transmural action potential duration disp

SUBMITTER: Glukhov AV 

PROVIDER: S-EPMC3351089 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature