HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis.

ABSTRACT:

Background

HOX genes encode homeodomain-containing transcription factors involved in the regulation of cellular proliferation and differentiation during embryogenesis. However, members of this family demonstrated oncogenic properties in some malignancies. The present study investigated whether genes of the HOXA cluster play a role in oral cancer.

Methods

In order to identify differentially expressed HOXA genes, duplex RT-PCR in oral samples from healthy mucosa and squamous cell carcinoma was used. The effects of HOXA1 on proliferation, apoptosis, adhesion, invasion, epithelial-mesenchymal transition (EMT) and anchorage-independent growth were assessed in cells with up- and down-regulation of HOXA1. Immunohistochemical analysis using a tissue microarray (TMA) containing 127 o

SUBMITTER: Bitu CC 

PROVIDER: S-EPMC3351375 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature