Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis.

ABSTRACT:

Background

Sputum Mycobacterium tuberculosis (Mtb) culture is commonly used to assess response to antibiotic treatment in individuals with pulmonary tuberculosis (TB). Such techniques are constrained by the slow growth rate of Mtb, and more sensitive methods to monitor Mtb clearance are needed. The goal of this study was to evaluate changes in plasma cytokines in patients undergoing treatment for TB as a means of identifying candidate host markers associated with microbiologic response to therapy.

Methods

Twenty-four plasma cytokines/chemokines were measured in 42 individuals diagnosed with active pulmonary TB, 52% were HIV co-infected. Individuals, undergoing a 26-week standard TB treatment, were followed longitudinally over 18 months and measurements were associated with H

SUBMITTER: Riou C 

PROVIDER: S-EPMC3351475 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature