Predicting infectious complications in neutropenic children and young people with cancer (IPD protocol).

ABSTRACT:

Background

A common and potentially life-threatening complication of the treatment of childhood cancer is infection, which frequently presents as fever with neutropenia. The standard management of such episodes is the extensive use of intravenous antibiotics, and though it produces excellent survival rates of over 95%, it greatly inconveniences the three-fourths of patients who do not require such aggressive treatment. There have been a number of studies which have aimed to develop risk prediction models to stratify treatment. Individual participant data (IPD) meta-analysis in therapeutic studies has been developed to improve the precision and reliability of answers to questions of treatment effect and recently have been suggested to be used to answer questions regarding prognosis

SUBMITTER: Phillips RS 

PROVIDER: S-EPMC3351734 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature