Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.

ABSTRACT:

Background

Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.

Methods

We investigated the association of rs1051730 and rs16969968 genotype (referred to as rs1051730-rs16969968, because these are in perfect linkage disequilibrium and interchangeable) with both self-reported daily cigarette consumption and biochemically measured plasma or serum cotinine levels among cigarette smokers. Summary estimates and descriptive stati

SUBMITTER: Munafo MR 

PROVIDER: S-EPMC3352832 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature