Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.

ABSTRACT: A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC3353021 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature