Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium.

ABSTRACT:

Background

Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis.

Methods

Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations usi

SUBMITTER: Grover M 

PROVIDER: S-EPMC3353102 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature