Distribution of human CYP2C8*2 allele in three different African populations.

ABSTRACT:

Background

The aim of this study was to investigate cytochrome P450 2C8*2 (CYP2C8*2) distribution and allele frequency in three populations from West and East Africa exposed to Plasmodium falciparum malaria. CYP2C8 enzyme is involved in the metabolism of the anti-malarials amodiaquine and chloroquine. The presence of the CYP2C8*2 defective allele has been recently associated to higher rate of chloroquine-resistant malaria parasites.

Methods

A total of 503 young subjects were genotyped for the single nucleotide polymorphism rs11572103 (A/T). Eighty-eight were from southern Senegal, 262 from eastern Uganda and 153 from southern Madagascar. The PCR-RFLP technique was used to discriminate the wild-type (A) from the defective allele (T).

Results

A CYP2C8*2 (T) allele frequ

SUBMITTER: Paganotti GM 

PROVIDER: S-EPMC3353233 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature