Ontology highlight
ABSTRACT:
SUBMITTER: Das PP
PROVIDER: S-EPMC3353317 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20080619 1
The Piwi proteins of the Argonaute superfamily are required for normal germline development in Drosophila, zebrafish, and mice and associate with 24-30 nucleotide RNAs termed piRNAs. We identify a class of 21 nucleotide RNAs, previously named 21U-RNAs, as the piRNAs of C. elegans. Piwi and piRNA expression is restricted to the male and female germline and independent of many proteins in other small-RNA pathways, including DCR-1. We show that Piwi is specifically required to silence Tc3, but not ...[more]