Algae-produced Pfs25 elicits antibodies that inhibit malaria transmission.

ABSTRACT: Subunit vaccines are significantly more expensive to produce than traditional vaccines because they are based primarily on recombinant proteins that must be purified from the expression system. Despite the increased cost, subunit vaccines are being developed because they are safe, effective, and can elicit antibodies that confer protection against diseases that are not currently vaccine-preventable. Algae are an attractive platform for producing subunit vaccines because they are relatively inexpensive to grow, genetically tractable, easily scaled to large volumes, have a short generation time, and are devoid of inflammatory, viral, or prion contaminants often present in other systems. We tested whether algal chloroplasts can produce malaria transmission blocking vaccine candidates, Plasmod

SUBMITTER: Gregory JA 

PROVIDER: S-EPMC3353897 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature