Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity.

ABSTRACT:

Objective

The enlarged adipose tissue in obesity is characterized by inflammation, including the recruitment and infiltration of macrophages and lymphocytes. The objective of this study was to investigate the role of the scavenger receptor CD36 in high fat diet-induced obesity and adipose tissue inflammation and cell death.

Experimental approach

Obesity and adipose tissue inflammation was compared in CD36 deficient (CD36 KO) mice and wild type (WT) mice fed a high fat diet (60% kcal fat) for 16 weeks and the inflammatory response was studied in primary adipocytes and macrophages isolated from CD36 KO and WT mice.

Results

Compared to WT mice, CD36 KO mice fed a high fat diet exhibited reduced adiposity and adipose tissue inflammation, with decreased adipocyte cell deat

SUBMITTER: Cai L 

PROVIDER: S-EPMC3353961 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature