Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis.

ABSTRACT: Amino-acid starvation leads to an inhibition of cellular proliferation and the induction of programmed cell death (PCD) in the Drosophila ovary. Disruption of insulin signaling has been shown to inhibit the progression of oogenesis, but it is unclear whether this phenotype mimics starvation. Here, we investigate whether the insulin-mediated phosphoinositide kinase-3 pathway regulates PCD in mid oogenesis. We reasoned that under well-fed conditions, disruption of positive components of the insulin signaling pathway within the germline would mimic starvation and produce degenerating egg chambers. Surprisingly, mutants did not mimic starvation but instead produced many abnormal egg chambers in which the somatic follicle cells disappeared and the germline persisted. These abnormal egg chambers

SUBMITTER: Pritchett TL 

PROVIDER: S-EPMC3354059 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature