The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.

ABSTRACT: In the genome of Aspergillus nidulans, a defensin-like protein, Anisin1, was annotated with high homology to the mosquito defensin AaDefA1. So far, no studies exist on defensins from filamentous ascomycetes. Therefore, we characterized the anisin1 gene in A. nidulans and generated a deletion mutant, which suffered from a defect in mitospore development and produced less conidia at 42°C compared to the reference strain. In surface cultures of A. nidulans wild type, the anisin1 expression correlated with that of the central regulator for asexual development, brlA, and with the major scavanger of H(2)O(2) stress, catB, which is indicative for cell differentiation in developing fungi. Interestingly, brlA and anisin1 expressions were deregulated in a ΔsrrA strain that covers a central role in t

SUBMITTER: Eigentler A 

PROVIDER: S-EPMC3354322 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature