Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis.

ABSTRACT:

Objective

Recent advances in molecular techniques have revealed that there is bi-directional transfer of cells between mother and child during pregnancy, and the presence of a mother's cells in her child has been termed maternal microchimerism (MMc). There is the potential for maternal cells to provoke inappropriate immune responses in the child, which could be a factor in autoimmunity including JDM. The aim of this study was to determine whether maternal (female) cells could be detected in frozen muscle sections from seven males (age range 3-13 years) with JDM participating in the Juvenile Dermatomyositis National (U.K. and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies and sections of muscle controls (age range 2-12 years).

Methods

At

SUBMITTER: Ye Y 

PROVIDER: S-EPMC3354676 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature