A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

ABSTRACT:

Objective

To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study.

Methods

We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and approximately 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values <1 x 10(-7) considered genome-wide significant.

Results

The C allele of rs3815148 on chromosome 7q22 (minor allele frequency 23%; intron 12 of the COG5 gene) was associated with a 1.14-fold increased risk (95% confidence interval 1.09-1.19) of knee and/or hand OA (P = 8 x 10(-8)) and also with a 30% increased risk of knee OA

SUBMITTER: Kerkhof HJ 

PROVIDER: S-EPMC3354739 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature