Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development.

ABSTRACT: Modifications to the treatment of acute lymphoblastic leukaemia (ALL) in children have led to a dramatic increase in survival in the past 40 years. Despite this success, a significant subset of paediatric leukaemia patients either relapse or fail to ever achieve a complete remission. Additionally, some patients necessitate treatment with intensified chemotherapy regimens due to clinical or laboratory findings which identify them as high risk. These patients are unlikely to respond to further minor adjustments to the dosing or timing of administration of the same chemotherapy medications. Many novel targeted therapies for the treatment of childhood ALL provide potential mechanisms to further improve cure rates, and provide the possibility of minimizing toxicity to non-malignant cells, given

SUBMITTER: Lee-Sherick AB 

PROVIDER: S-EPMC3354740 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature