Plant polyphenols as electron donors for erythrocyte plasma membrane redox system: validation through in silico approach.

ABSTRACT:

Background

The plasma membrane redox system (PMRS) has extensively been studied in erythrocytes. The PMRS plays an important role in maintaining plasma redox balance and provides a protective mechanism against oxidative stress. Earlier it was proposed that only NADH or NADPH provided reducing equivalents to PMRS; however, now it is acknowledged that some polyphenols also have the ability to donate reducing equivalents to PMRS.

Methods

Two different docking simulation softwares, Molegro Virtual Docker and Glide were used to study the interaction of certain plant polyphenols viz. quercetin, epigallocatechin gallate, catechin epicatechin and resveratrol with human erythroyte NADH-cytochrome b5 reductase, which is a component of PMRS and together with the identification of minim

SUBMITTER: Kesharwani RK 

PROVIDER: S-EPMC3355021 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature