Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer.

ABSTRACT:

Background

Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenic process.

Methods

We used data from two population-based case-control studies of colon (n = 1555 cases, 1956 controls) and rectal (n = 754 cases, 959 controls) cancer. We evaluated the association between genetic variation in TXNRD1, TXNRD2, TXNRD3, C11orf31 (SelH), SelW, SelN1, SelS, SepX, and SeP15 with colorectal cancer risk.

Results

After adjustment for multiple comparisons, several associations were observed. Two SNPs in TXNRD3 were associated with rectal cancer (rs11718498 dominant OR 1.42 95% CI 1.16,1.74 pACT 0.0036 and rs9637365 recessive 0.70 95% CI 0.55,0.90 pACT 0.0208). Four SNPs in SepN1 were associated with rectal cancer (rs11247735 r

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC3355111 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature