CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

ABSTRACT:

Background

Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis via cognate chemokine receptors. For efficient migration, receptor responsiveness must be maintained whilst the cells crawl on cell surfaces or on matrices along the attracting gradient towards increasing concentrations of agonist. On the other hand agonist-induced desensitization and internalization is a general paradigm for chemokine receptors which is inconsistent with the prolonged migratory capacity.

Methodology/principal findings

Chemotaxis of monocytes was monitored in response to fluorescent CCL2-mCherry by time-lapse

SUBMITTER: Volpe S 

PROVIDER: S-EPMC3355119 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature