A meta-analysis of caspase 9 polymorphisms in promoter and exon sequence on cancer susceptibility.

ABSTRACT:

Background

Caspases are important regulators and executioners in apoptosis pathway and have been defined as either tumor suppressors or oncogenes. Polymorphisms in promoter and exon of caspase 9 were shown to confer genetic susceptibility to multiple cancers, but the results were inconsistent. To accomplish a more precise estimation of the relationship, a meta-analysis was performed.

Methodology/principal findings

We assessed published studies of the association between caspase 9 polymorphisms and cancer risk from nine studies with 5,528 subjects for rs4645978, six studies with 2,403 subjects for rs105276 and two studies for rs4645981. Overall meta-analysis indicated that no evidence of an association between rs4645978 and cancers was found. Through the stratified analysis,

SUBMITTER: Xu W 

PROVIDER: S-EPMC3355128 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature