The prognostic role of RASSF1A promoter methylation in breast cancer: a meta-analysis of published data.

ABSTRACT:

Purpose

Epigenetic alterations have been investigated as prognostic indicators in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. We present the results of a meta-analysis of the associations between RASSF1A promoter methylation status and both disease free survival (DFS) and overall survival (OS) in female breast cancer.

Methods

Eligible studies were identified through searching the PubMed, Web of Science and Embase databases. Studies were pooled and summary hazard ratios (HR) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also carried out to evaluate publication bias.

Results

A total of 1795 patients from eight studies were included in the meta-analysis. There are eigh

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC3355150 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature