Population heterogeneity in trajectories of midlife blood pressure.

ABSTRACT:

Background

We investigated whether there are subgroups with different underlying (latent) trajectories of midlife systolic blood pressure (BP), diastolic BP, and pulse pressure in a UK cohort.

Methods

Data are from 1840 men and 1819 women with BP measured at ages 36, 43, and 53 years. We used unconditional growth mixture models to test for the presence of latent trajectory classes. Extracted classes were described in terms of a number of known lifetime risk factors, and linked to the risk of undiagnosed angina (Rose questionnaire) at age 53 years.

Results

In both sexes for systolic BP, diastolic BP, and pulse pressure, there was a large "normative" class (>90% of the sample) characterized by gentle annual increases (eg, an increase in male systolic BP of 0.9 mm Hg/yea

SUBMITTER: Wills AK 

PROVIDER: S-EPMC3355297 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature