Irritancy and allergic responses induced by exposure to the indoor air chemical 4-oxopentanal.

ABSTRACT: Over the last two decades, there has been an increasing awareness regarding the potential impact of indoor air pollution on human health. People working in an indoor environment often experience symptoms such as eye, nose, and throat irritation. Investigations into these complaints have ascribed the effects, in part, to compounds emitted from building materials, cleaning/consumer products, and indoor chemistry. One suspect indoor air contaminant that has been identified is the dicarbonyl 4-oxopentanal (4-OPA). 4-OPA is generated through the ozonolysis of squalene and several high-volume production compounds that are commonly found indoors. Following preliminary workplace sampling that identified the presence of 4-OPA, these studies examined the inflammatory and allergic responses to 4-OPA

SUBMITTER: Anderson SE 

PROVIDER: S-EPMC3355310 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature