Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

ABSTRACT: The genetically tractable filamentous ascomycete fungus Aspergillus nidulans has been successfully exploited to gain major insight into the eukaryotic cell cycle. More recently, its amenability to in vivo multidimensional microscopy has fueled a potentially gilded second age of A. nidulans cell biology studies. This review specifically deals with studies on intracellular membrane traffic in A. nidulans. The cellular logistics are subordinated to the needs imposed by the polarized mode of growth of the multinucleated hyphal tip cells, whereas membrane traffic is adapted to the large intracellular distances. Recent work illustrates the usefulness of this fungus for morphological and biochemical studies on endosome and Golgi maturation, and on the role of microtubule-dependent motors in the l

SUBMITTER: Penalva MA 

PROVIDER: S-EPMC3355971 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature